Scientists from Australia and the UK have completed the most comprehensive analysis yet of pancreatic cancer, in a study that could improve future treatments.
The international study has revealed four sub types of the disease.
The research team was led by Professor Sean Grimmond from UQ’s Institute for Molecular Bioscience and Professor Andrew Biankin from Sydney’s Garvan Institute of Medical Research and the University of New South Wales, and included bioinformatician Dr Nicola Waddell from Brisbane’s QIMR Berghofer Medical Research Institute.
The analysis used a technique called whole genome sequencing to determine the complete genetic code of pancreatic tumors in 100 patients, with the data published in Nature.
The team identified and mapped detailed patterns of ‘structural variation’ to reveal the extensive and damaging genetic changes that drive the formation of four cancer subtypes.
Professor Grimmond said this gave researchers a deeper understanding of the complex genomic landscape of pancreatic cancer.
“Whole genome sequencing gave us unprecedented access to explore the history of each patient’s genome, including how their genes and chromosomes had rearranged and accumulated damage over time,” he said.
The identification of four different subtypes meant there was potential to treat each type differently.
“Having access to these detailed genetic maps could help doctors in the future determine which chemotherapy drug a patient should get, based on their cancer’s genome.”
QIMR Berghofer bioinformatician Dr Nicola Waddell (formerly of UQ IMB) said pancreatic cancer remained one of the most complex cancers to treat.
“Our study identified four major genomic subtypes in pancreatic cancer, revealed two new driver genes not previously associated with pancreatic cancer, and reaffirmed the importance of five key genes.
“These findings could prove promising in diagnosing and treating the disease in future.”
Professor Biankin and Professor Grimmond plan to conduct a clinical trial in the UK, selecting patients for targeted treatments based on genomic testing.
Pancreatic cancer is the fifth-leading cause of cancer death in Australia.
Source: University of Queensland
